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Yes, they will work on the wheels, but not with a stock suspension, you'll need a 2" lift to squeeze them in since your factory suspension has dropped over 1.5"s from new.
If you're trying to fit the biggest tire you can, I suggest 255/60r18.
That's what im running and it fills out the wheel well just fine.
Like Mike said, that size will fit the wheels, but you'll need to do a little extra work to make it possible.