had the computer scanned with obd II computer. came back that there was a misfire on cylinder 1, 8, 2, 3. I replaced the wires and still problem is there. idles well, runs very rough when accleerating. Anybody know?

 

What were the exact codes, how many miles on the truck, how about the plugs, what brand and gap, what about your gas, what octane?

 

The plugs have been replaced in the last 2 weeks, they were not gapped. it threw a code for a misfire on the cylinders listed above. dont knwo the exact code numbers. truck hasd 105K on the odometer. alwasy ran 87 on it for lat 5 years..think it might be coil due to all of the cylinder misfireing on those specifinc cylinders. are they all on the same coil?

 

If you want help, you really need to answer the question replyed back to you so we know what you are dealing with.
What brand of plugs and wires and what year is it??
For sure you have carboned up your valves, burning cheap gas, hopefully you haven't damaged the valve stem seals.