Calibrate the suspension at factory height, then get an allignment done. To answer your question, it absolutely will affect suspension geometry and tire wear if you change it.

Driving it lifted more than that is pointless, driving it lowered even more so. Increased tire wear for marginal fuel savings or handling (EAS adjusts automatically at highways speeds anyway) also pointless. The car already handles far better than many, many vehicles at FACTORY settings.

Only possible exception is if you are a drug lord with poor taste or as Abran mentioned have a health or disability exigency. Access height is 90% of the way there but still too high for some folks. Seen it, used it.

Nobody else should be doing this.